Information

Research in epithelial transport

Richard Boyd MA MSc BM BChir DPhil FMedSci

University Lecturer
Tel.: 01865 272169
Fax: 01865 272420
Email: richard.boyd@anat.ox.ac.uk

This laboratory has as its focus the experimental study of transporters and their regulation. We work on peptide transporters, both cloned and expressed in Xenopus oocytes and in intact tissues. We also study molecular and functional aspects of amino acid transporters, specifically with respect to heterodimeric transporters and the function of the CD98 heavy chain (Devés & Boyd 2000). The role of such transporters in nitric oxide biology is being studied in relation to human septic shock (Reade et al. 2002). A new area of experimental study is the molecular basis for regulation of transport in the placenta specifically with respect to fetal growth (Kudo & Boyd 2002a), placental development (Kudo & Boyd 2002b) and pre-eclampsia (Kudo et al. 2003). For these studies a novel assay of cell fusion has been developed (Kudo et al. 2002). The regulation of transport of small peptides is funded by a Wellcome Trust programme grant. The group also has funding from the MRC and Action Research.

Current Funding: Wellcome Trust (Programme and project grants), MRC and Action Research

Other activities: Senior Fellow in Medicine, Brasenose College; Editor, Pflügers Archiv, Surgery & Physiological Genomics. RAE panel member

Model of peptide uptake and transport

Key Publications

Reade M, Clark MF, Young JD & Boyd CAR (2002). Clinical Sci. 102, 645-50.
Hussain I, Kellett L, Affleck J, Shepherd J, Boyd CAR (2002) Cell Tissue Res. 307, 139-42.
Kudo Y & Boyd CAR (2002a) Reproduction. 124, 593-600
Kudo Y & Boyd CAR (2002b) Placenta. 23, 536-41
Kudo Y et al. (2002) Biochemica Biophysica Acta (in press).
Kudo Y et al. (2003) American Journal of Obstetrics (in press).
Devés, R. & Boyd, CAR (2000) J MembBiol 173, 165-177.

Main Collaborators

Professor PD Bailey, Manchester
Dr G L Kellett, York
Professor R Devés, Chile
Professor C Redman, Oxford
Professor D Sattelle, Oxford
Dr C Temple, Cell Tech
Dr J D Young, Oxford
Dr P Ayuk, Oxford

Group Members

Mr R W Laynes (Technician)
Dr D Meredith (Wellcome Trust Senior Post-doctoral Scientist)

Dr Michael Reade (Clinical Trainee Fellow)
Dr Nicola McCord (Clinical Trainee Fellow)
Miss Sarah Kelly (MRC Collaborative Student)
Miss Sabrina Sandrasagra (Merton College)
Mrs Luanda Pym (MRC Joint Student)
Mr Konstantinos Panitsas (Wellcome Trust Prize Student)